تفاعل #1553216

معادلة التفاعل

NaHMDS

THF

1-Oxoindane-5-carbonitrile

THF

THF

→

title compound

1-(Methoxymethylene)indane-5-carbonitrile

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe mixture was stirred for 2 hours at 0° C
2. 2
   أخرىThe reaction was quenched with water
3. 3
   استخلاصextracted with EtOAc
4. 4
   غسيلThe combined organic phase was washed with brine
5. 5
   تجفيفdried over anhydrous Na2SO4
6. 6
   تركيزconcentrated
7. 7
   أخرىThe residue was purified by silica gel column chromatograph

الإجراء التجريبي

To a mixture of CH3OCH2PPh3I (8.9 g, 26 mmol) in THF (80 mL) was added a solution of NaHMDS in THF (2.0M, 13 mL, 26 mmol)) at 0° C. The mixture was stirred 1 hour at 0° C. Then a solution of 1-Oxoindane-5-carbonitrile (2.0 g, 13 mmol) in THF (10 mL) was added. The mixture was stirred for 2 hours at 0° C. The reaction was quenched with water and extracted with EtOAc. The combined organic phase was washed with brine, dried over anhydrous Na2SO4 and concentrated. The residue was purified by silica gel column chromatograph to give the title compound. MS m/z: 186 [M+1]+.

المصدر