تفاعل #155319

معادلة التفاعل

5-Methylbenzofuran-7-ylamine

ethanol

→

5-methyl-2,3-dihydrobenzofuran-7-ylamine

المردود 87.6%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىfollowed by conduction of catalytic reduction at room temperature under ordinary pressure
2. 2
   أخرىThe catalyst was removed by celite filtration
3. 3
   أخرىcondensed under reduced pressure
4. 4
   تجفيفdried over anhydrous magnesium sulfate
5. 5
   تركيزconcentrated to dryness under reduced pressure

الإجراء التجريبي

5-Methylbenzofuran-7-ylamine (1.3 g, 8.8 mmol) and 10% palladium carbon (500 mg) were added to ethanol (50 ml), followed by conduction of catalytic reduction at room temperature under ordinary pressure. The catalyst was removed by celite filtration, and the obtained filtrate was condensed under reduced pressure. The residue was dissolved in dichloromethane, dried over anhydrous magnesium sulfate, and then concentrated to dryness under reduced pressure, giving a white powder of 5-methyl-2,3-dihydrobenzofuran-7-ylamine (1.15 g, yield: 87%).

المصدر