تفاعل #155310

معادلة التفاعل

N-(3-Propoxynaphthalen-2-yl)acetamide

hydrochloric acid

sodium hydroxide

→

3-propoxynaphthalen-2-ylamine

المردود 100.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwhile heating
2. 2
   درجة الحرارةunder reflux
3. 3
   استخلاصfollowed by extraction
4. 4
   تركيزThe thus-obtained organic layer was concentrated to dryness under reduced pressure
5. 5
   أخرىthe residue was then purified
6. 6
   تركيزThe purified product was concentrated to dryness under reduced pressure

الإجراء التجريبي

N-(3-Propoxynaphthalen-2-yl)acetamide (2.5 g, 10.2 mmol) was dissolved in ethanol (10 ml). Concentrated hydrochloric acid (5.2 ml) was added thereto, and the resulting mixture was stirred for 4 hours while heating under reflux. The reaction mixture was cooled to room temperature, and a 5N aqueous sodium hydroxide solution (12.5 ml) was added thereto to adjust its pH to 11, followed by extraction using dichloromethane. The thus-obtained organic layer was concentrated to dryness under reduced pressure, and the residue was then purified using silica gel column chromatography (dichloromethane). The purified product was concentrated to dryness under reduced pressure, giving a white powder of 3-propoxynaphthalen-2-ylamine (2.05 g, yield: 100%).

المصدر