تفاعل #1552041

معادلة التفاعل

1-(3-dimethylamino propyl)-3-ethyl carbodiimide hydrochloride

phenylalanine

2-(phenylseleno)ethanol

THF

→

N-acetylphenylalanine 2-(phenylseleno)ethyl ester

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with 50 ml of a 0.5 M HCl solution
2. 2
   تجفيفThe organic phase was dried over sodium sulfate
3. 3
   ترشيحfiltered
4. 4
   أخرىthe solvent was removed in vacuo
5. 5
   أخرىPurification by column chromatography (PE:EE=2:1)
6. 6
   أخرىyielded 2.9 g (91% of th., 98% of lit.) of a yellowish liquid

الإجراء التجريبي

In a 50 ml round bottomed flask, 2.55 g (13.3 mmol) of 1-(3-dimethylamino propyl)-3-ethyl carbodiimide hydrochloride and 1.7 g of (8.2 mmol) phenylalanine were added to a solution of 1.87 g (9.3 mmol) of 2-(phenylseleno)ethanol in 20 ml of THF. The reaction mixture was then stirred for 12 hours at room temperature. The mixture was then diluted with 50 ml of ethyl acetate and extracted with 50 ml of a 0.5 M HCl solution. The organic phase was dried over sodium sulfate, filtered, and the solvent was removed in vacuo. Purification by column chromatography (PE:EE=2:1) yielded 2.9 g (91% of th., 98% of lit.) of a yellowish liquid.

المصدر