تفاعل #1552036

ord-b2bfde9ed2a34503855b977f3d67f798

معادلة التفاعل

CC(C)(C)CC(C)(C)NC(=O)c1ccc([N+](=O)[O-])cc1
4-Nitro-N-(tert-octyl)benzamide
[H][H]
hydrogen
→
CC(C)(C)CC(C)(C)NC(=O)c1ccc(N)cc1
4-amino-N-(tert-octyl)benzamide
المردود 76.1%

المتفاعلات

CC(C)(C)CC(C)(C)NC(=O)c1ccc([N+](=O)[O-])cc1
4-Nitro-N-(tert-octyl)benzamide
[H][H]
hydrogen

الكواشف

[Pd]
palladium-on-charcoal
O
water

المذيبات

CCOC(C)=O
ethyl acetate

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرى15 minutes
  2. 2
    ترشيحAfter filtration, concentration of the solvent

الإجراء التجريبي

4-Nitro-N-(tert-octyl)benzamide (30 g, 0.108 mol) dissolved in 200 ml of ethyl acetate is hydrogenated, in a 500 ml hydrogenator, in the presence of 4.8 g of 10% palladium-on-charcoal containing 50% of water, as catalyst (hydrogen pressure: 8-10 bar), at a temperature of 70-75° C. for 1 hour and 15 minutes. After filtration, concentration of the solvent and drying under vacuum, 20.4 g (yield: 76%) of 4-amino-N-(tert-octyl)benzamide are obtained in the form of a light yellow powder, which is used as it is in the following stage.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08999299B2uspto-grants-2015_04