تفاعل #1552019

معادلة التفاعل

methyl ethyl ketone

4-hydroxybiphenyl

6-bromo-1-hexanol

potassium carbonate

→

6-(4-phenylphenoxy)hexane-1-ol

المردود 75.8%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThis solution was refluxed for 24 hours
2. 2
   غسيلrinsed with water three times
3. 3
   أخرىThe organic phase was then separated
4. 4
   تجفيفdried over magnesium sulfate
5. 5
   workup.DISTILLATIONthe solvent was distilled off
6. 6
   workup.DISSOLUTIONThe residue was dissolved in toluene
7. 7
   أخرىpurified by recrystallization

الإجراء التجريبي

To 80 mL of methyl ethyl ketone, 9.05 g (50 mmol) of 4-hydroxybiphenyl, 10.20 g (60 mmol) of 6-bromo-1-hexanol, and 20.7 g (150 mmol) of potassium carbonate were added. This solution was refluxed for 24 hours and then cooled to room temperature. This solution was diluted with 200 mL of methylene chloride and rinsed with water three times. The organic phase was then separated and dried over magnesium sulfate, and the solvent was distilled off. The residue was dissolved in toluene and purified by recrystallization to provide 10.25 g of 6-(4-phenylphenoxy)hexane-1-ol.

المصدر