تفاعل #1550103

معادلة التفاعل

methyl 3-hydroxycyclohexanecarboxylate

2,3-dihydropyran

→

methyl 3-(2-tetrahydropyranyloxy)cyclohexanecarboxylate

المردود 65.8%

المذيبات

ether

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water
2. 2
   تجفيفdried (MgSO4)
3. 3
   workup.DISTILLATIONThe ether was distilled off
4. 4
   workup.DISTILLATIONthe oily residue was distilled under reduced pressure

الإجراء التجريبي

To a solution of methyl 3-hydroxycyclohexanecarboxylate [J. Am. Chem. Soc., 70, 1898 (1948)] (61 g) in ether (500 ml), 2,3-dihydropyran (49 g) and p-toluenesulfonic acid monohydrate (1 g) were added. The mixture was stirred at room temperature for 6 hours and washed with water and dried (MgSO4). The ether was distilled off, and the oily residue was distilled under reduced pressure to give methyl 3-(2-tetrahydropyranyloxy)cyclohexanecarboxylate (61.5 g, 60.2%, b.p. 120°-123° C./0.3 mmHg).

المصدر