تفاعل #1533

معادلة التفاعل

N-t-butyl-3-(1-aceoxy-2-fluoroethyl) 2-thiophenesulfonamide

N-t-butyl-3-(1-acetoxy-2-fluoroethyl)-2-thiophenesulfonamide

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pure title compound

المردود 74.0%

3-(1-acetoxy-2-fluoroethyl)-2-thiophenesulfonamide

المردود 74.0%

المذيبات

trifluoroacetic acid

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated under reduced pressure
2. 2
   workup.DISSOLUTIONThe residue was dissolved in methylene chloride
3. 3
   غسيلwashed with aqueous sodium bicarbonate solution
4. 4
   أخرىThe organic layer was separated
5. 5
   تجفيفdried over anhydrous magnesium sulfate
6. 6
   ترشيحfiltered
7. 7
   تركيزThe filtrate was concentrated
8. 8
   أخرىThe residue was recrystallized

الإجراء التجريبي

1.4 g (0.0043 mole) of N-t-butyl-3-(1-aceoxy-2-fluoroethyl) -2-thiophenesulfonamide synthesized in Example 2 dissolved in 5 ml of trifluoroacetic acid. The reaction solution was stirred at normal temperature for 12 hours and then concentrated under reduced pressure. The residue was dissolved in methylene chloride and washed with aqueous sodium bicarbonate solution. The organic layer was separated, dried over anhydrous magnesium sulfate and then filtered. The filtrate was concentrated. The residue was recrystallized to obtain 750 mg (Yield: 74%) of the pure title compound as a white solid.

المصدر