تفاعل #1519695

معادلة التفاعل

(+)-Limonene oxide

lithium chloride

Morpholine

→

product

المردود 49.5%

4-Isopropenyl-1-methyl-2-morpholin-4-yl-cyclohexanol

المردود 49.5%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe reaction mixture was heated at 60° for 48 hours
2. 2
   أخرىThe solvent was evaporated under reduced pressure
3. 3
   غسيلWashed with water
4. 4
   استخلاصExtracted into 2M hydrochloric acid
5. 5
   غسيلwashed with dichloromethane
6. 6
   workup.ADDITIONBasified to pH 10 by addition of 2M sodium hydroxide
7. 7
   استخلاصExtracted with diethyl ether
8. 8
   غسيلwashed with water
9. 9
   تجفيفDried over anhydrous magnesium sulphate
10. 10
    أخرىevaporated the solvent under reduced pressure

الإجراء التجريبي

(+)-Limonene oxide (13.2 g, 0.087 moles) was dissolved in ethanol (40 ml) and lithium chloride (5.9 g, 0.14 moles) was added with stirring. Morpholine (11.4 g, 0.13 moles) was added and the reaction mixture was heated at 60° for 48 hours. The solvent was evaporated under reduced pressure and the residue taken up in dichloromethane. Washed with water. Extracted into 2M hydrochloric acid and washed with dichloromethane. Basified to pH 10 by addition of 2M sodium hydroxide. Extracted with diethyl ether and washed with water. Dried over anhydrous magnesium sulphate and evaporated the solvent under reduced pressure to give the product as a yellow oil (10.3 g)

المصدر