تفاعل #1519120

معادلة التفاعل

Z-L-Pro-OH

thionyl chloride

→

Z-L-Pro-Cl

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis heated
2. 2
   درجة الحرارةto reflux under nitrogen for 20 minutes
3. 3
   تركيزconcentrated in vacuo
4. 4
   تركيزconcentrated

الإجراء التجريبي

A mixture of Z-L-Pro-OH E-1 (10.0 g, 40.1 mmol, 1 equiv.) and thionyl chloride (30 mL, 401.2 mmol, 10 equiv.) in DCM (200 mL) is heated to reflux under nitrogen for 20 minutes and concentrated in vacuo. The residual oil is coevaporated with toluene 3×, and concentrated to give Z-L-Pro-Cl as an opaque oil.

المصدر