تفاعل #1519118

معادلة التفاعل

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid

p-TSA

→

2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid

المذيبات

DCM

2,2-dimethoxypropane

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with brine
2. 2
   تجفيفdried (Na2SO4)
3. 3
   أخرىpurified by silica gel chromatography

الإجراء التجريبي

To a solution of (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid B-4 (300 mg, 1.58 mmol) in 2,2-dimethoxypropane (10 mL) is added p-TSA (20 mg) and the reaction is stirred at rt for 16 hours. The solution is diluted with DCM and washed with brine, dried (Na2SO4) and then purified by silica gel chromatography to afford 1.2 mmol 2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid B-5.

المصدر