تفاعل #1519117

معادلة التفاعل

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester

NaOH

HCl

→

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid

المذيبات

MeOH

water

ظروف التفاعل

المعالجة

1. 1
   أخرىthe MeOH is removed
2. 2
   أخرىthe crude reaction
3. 3
   استخلاصextracted with EtOAc (3×50 mL)
4. 4
   تجفيفThe combined organic layers are dried (Na2SO4)
5. 5
   تركيزconcentrated

الإجراء التجريبي

To (2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester B-3 in MeOH (28 mL) is added a solution of NaOH (2.2 g, 55 mmol) in water (28 mL). After 24 hours, the MeOH is removed, the crude reaction is acidified with HCl (6 N, 12 mL) to pH=1, and then extracted with EtOAc (3×50 mL). The combined organic layers are dried (Na2SO4) and concentrated to give (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid B-4.

المصدر