تفاعل #1519111

معادلة التفاعل

Ethyl 2-(Formylaminothiazol-4-yl)-2-oxoacetate

N-Chlorosuccinimide

water

→

title intermediate

Ethyl 2-(2-Formylamino-5-chlorothiazol-4-yl)-2-oxoacetate

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe resulting white precipitate was filtered
2. 2
   غسيلwashed with water and air
3. 3
   أخرىdried

الإجراء التجريبي

Ethyl 2-(Formylaminothiazol-4-yl)-2-oxoacetate (9.1 g, 39.87 mmol) (obtained from Aldrich, Milwaukee, Wis.) was slurried in 50 mL of anhydrous DMF. N-Chlorosuccinimide (5.6 g, 41.86 mmol) was added as a solid and the suspension was stirred at room temperature. After 18 hours, the reaction mixture was poured into 500 mL of water. The resulting white precipitate was filtered, washed with water and air dried to afford the title intermediate as a white solid.

المصدر