تفاعل #1519086

معادلة التفاعل

benzyl ether

6-{2-[2-(2-{2-[2-(2-Benzyloxyethoxy)ethoxy]ethoxy}-ethoxy)-ethoxy]-ethoxy}-hexanoic acid ethyl ester

→

compound 4

المردود 79.0%

6{2-[2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}-ethoxy)-ethoxy]-ethoxy}-hexanoic acid ethyl ester

المردود 79.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction mixture was filtered through Celite 545
2. 2
   أخرىto remove the catalyst
3. 3
   تركيزthe filtrate was concentrated in vacuo

الإجراء التجريبي

Substantially monodispersed benzyl ether 3 (1.03 g, 2.0 mmol) was dissolved in 25 ml ethanol. To this solution was added 270 mg 10% Pd/C, and the mixture was placed under a hydrogen atmosphere and stirred for four hours, at which time TLC showed the complete disappearance of the starting material. The reaction mixture was filtered through Celite 545 to remove the catalyst, and the filtrate was concentrated in vacuo to yield the monodispersed compound 4 as a clear oil (0.67 g, 79%). FAB MS: m/e 425 (M+H), 447 (M+Na).

المصدر