تفاعل #1512823
ord-ce9ad4eb9c2949558e5d8b0832362b27
معادلة التفاعل
المتفاعلات
الكواشف
لا شيء
المذيبات
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1أخرىInto a 50 mL round bottom flask equipped with magnetic stirrer and under an argon atmosphere
- 2تركيزThe light red brown solution was concentrated under reduced pressure
- 3أخرىthe residue was dried for 15 min
الإجراء التجريبي
Into a 50 mL round bottom flask equipped with magnetic stirrer and under an argon atmosphere was charged a solution of 0.305 parts of 10-methylacridan-9-carboxylic acid (77) in 15 mL of dichloromethane and cooled to 5° C. (ice-water). Then, 1.05 parts of thionyl chloride was added to the cold yellow acid solution and stirred for 1.5 hr at a temperature below 15° C. The light red brown solution was concentrated under reduced pressure and the residue was dried for 15 min to give acid chloride (78).