تفاعل #1512027

معادلة التفاعل

(2-chloro-4-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)phenyl)boronic acid

1,1,1-tris(hydroxymethyl)ethane

potassium t-butoxide THF

→

title compound

1-(2-Chloro-4-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)phenyl)-4-methyl-2,6,7-trioxa-1-borabicyclo[2.2.2]octan-1-uide potassium salt

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe resulting mixture was heated
2. 2
   درجة الحرارةto reflux for 4 hours
3. 3
   ترشيحThe mixture was filtered
4. 4
   أخرىto remove solids
5. 5
   تركيزthe filtrate concentrated to dryness at reduced pressure
6. 6
   workup.DISSOLUTIONThe residue was dissolved in 5 mL of anhydrous THF
7. 7
   درجة الحرارةthe solution cooled to 0° C
8. 8
   درجة الحرارةAfter warming to RT the solution
9. 9
   تركيزwas concentrated to dryness at reduced pressure

الإجراء التجريبي

To a stirred solution of (2-chloro-4-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)phenyl)boronic acid (0.0750 g, 0.135 mmol) and 1,1,1-tris(hydroxymethyl)ethane (0.0180 g, 0.148 mmol) in anhydrous THF (6 mL) was added activated 3 angstrom molecular sieves (0.400 g). The resulting mixture was heated to reflux for 4 hours and cooled to RT. The mixture was filtered to remove solids and the filtrate concentrated to dryness at reduced pressure. The residue was dissolved in 5 mL of anhydrous THF and the solution cooled to 0° C. The solution was treated with 1M potassium t-butoxide/THF (135 μL, 0.135 mmol) by dropwise addition. After warming to RT the solution was concentrated to dryness at reduced pressure to afford the title compound as a light yellow solid in quantitative yield. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.48 (d, J=4.0 Hz, 1H) 8.09 (s, 1H) 7.98 (dd, J=8.9, 5.5 Hz, 2H) 7.51 (d, J=7.9 Hz, 1H) 7.39 (t, J=8.9 Hz, 2H) 7.07-7.18 (m, 3H) 3.55 (s, 6H) 3.28 (s, 3H) 2.82 (d, J=3.4 Hz, 3H) 2.10-2.23 (m, 1H) 0.73-1.04 (m, 4H) 0.45 (s, 3H).

المصدر