تفاعل #1511353

معادلة التفاعل

(4R,5R)-3-(tert-butoxycarbonyl)-2,2,5-trimethyl-1,3-oxazolidine-4-carboxylic acid

3′,4′-diaminobiphenyl-4-carbonitrile

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title compound

4-{2-[(1S,2R)-1-Amino-2-hydroxypropyl]-1H-benzimidazol-5-yl}benzonitrile

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated in vacuo
2. 2
   أخرىpurified by SCX-2 cartridge (16 mg, 72%)

الإجراء التجريبي

The title compound was prepared according to Method 4 using (4R,5R)-3-(tert-butoxycarbonyl)-2,2,5-trimethyl-1,3-oxazolidine-4-carboxylic acid (Preparation 59A) and 3′,4′-diaminobiphenyl-4-carbonitrile (Preparation 82). The reaction mixture was concentrated in vacuo and purified by SCX-2 cartridge (16 mg, 72%).

المصدر