تفاعل #1509637

معادلة التفاعل

Compound 10

1-phenyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-benzo[d]imidazole

9-(4-bromophenyl)-9H-carbazole

KF

ethyl acetate

→

Compound 11

المردود 47.0%

9-(4′-(1-phenyl-1H-benzo[d]imidazol-2-yl)biphenyl-4-yl)-9H-carbazole

المردود 47.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling to r.t.
2. 2
   ترشيحThe resulting mixture was filtered
3. 3
   أخرىThe solid was collected
4. 4
   workup.DISSOLUTIONdissolved in DCM (200 mL)
5. 5
   ترشيحwhich was filtered
6. 6
   تركيزconcentrated
7. 7
   أخرىrecrystallized

الإجراء التجريبي

A mixture of Compound 10 (1.41 g, 3.56 mmol), 9-(4-bromophenyl)-9H-carbazole (1.15 g, 3.56 mmol), Pd(dppf)Cl2 (100 mg, 0.14 mmol) and KF (0.619 g, 10.7 mmol) in anhydrous DMF (20 mL) was heated at 120° C. under argon overnight. After cooling to r.t., ethyl acetate (200 mL) was added and the whole was stirred for 15 min. The resulting mixture was filtered. The solid was collected and dissolved in DCM (200 mL), which was filtered, concentrated and recrystallized to give a white solid (Compound 11) (550 mg).

المصدر