تفاعل #1509597
ord-a15aac5b07ea49c6bd015a4ccf3331e2
معادلة التفاعل
dimethylamine
2-Chloro-6-methyl-isonicotinic acid
DIPEA
TBTU
→
title compound
2-Chloro-6,N,N-trimethyl-isonicotinamide
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1استخلاصextracted with EtOAc
- 2أخرىThe organic layer was separated
- 3أخرىdried
- 4تركيزconcentrated in vacuum
الإجراء التجريبي
To a solution of 2-Chloro-6-methyl-isonicotinic acid (1 g) in DMF (200 ml) at 25° C. was added DIPEA (2.9 mL) and TBTU (1.8 ml). After 5 min, dimethylamine (0.75 g) was added dropwise. This was stirred overnight. The reaction was added to water and extracted with EtOAc. The organic layer was separated, dried and concentrated in vacuum. Flash:chromatography (9:1 to 2:8 gradient cyclohexane:EtOAc) afforded the title compound (320 mg). Rf=0.56 (1:1 cyclohexane:EtOAc)