تفاعل #1509592

معادلة التفاعل

3-(1-Methyl-1H-tetrazol-5-yl)-5-nitro-benzoic acid ethyl ester

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title compound

المردود 72.5%

3-Amino-5-(1-methyl-1H-tetrazol-5-yl)-benzoic acid ethyl ester

المردود 72.5%

المذيبات

EtOAc ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىwas hydrogenated at 20° C.
2. 2
   أخرىAfter reaction completion
3. 3
   ترشيحthe mixture was filtered
4. 4
   تركيزthe filtrate concentrated in vacuum

الإجراء التجريبي

A solution of 3-(1-Methyl-1H-tetrazol-5-yl)-5-nitro-benzoic acid ethyl ester (6.5 g) in EtOAc:ethanol (1:1, 320 ml) was hydrogenated at 20° C. and 50 psi with 10% Pd/C (750 mg). After reaction completion, the mixture was filtered and the filtrate concentrated in vacuum to give the title compound (4.2 g). Rt=1.21 min (method D).

المصدر