تفاعل #1509591

معادلة التفاعل

sodium azide

N-methyl-5-nitro-isophthalamic acid ethyl ester

NaHCO3

triflic anhydride

→

title compound

المردود 59.1%

3-(1-Methyl-1H-tetrazol-5-yl)-5-nitro-benzoic acid ethyl ester

المردود 59.1%

المذيبات

dichloroethane

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirred overnight
2. 2
   أخرىthe organic and aqueous layers were separated
3. 3
   أخرىthe organic layer dried
4. 4
   تركيزconcentrated in vacuum

الإجراء التجريبي

To a 2M solution of N-methyl-5-nitro-isophthalamic acid ethyl ester (10 g) in dichloroethane (200 ml) at −20° C. was added pre-cooled triflic anhydride (10 ml) dropwise. This was stirred for 30 min and then sodium azide (4.6 g) was added. This was allowed to warm to room temperature and stirred overnight. The reaction was neutralised with 5% NaHCO3 (aq) solution and the organic and aqueous layers were separated and the organic layer dried and concentrated in vacuum. Flash chromatography (100:0 to 50:50 gradient cyclohexane:EtOAc) afforded the title compound (6.5 g). Rt=1.52 min (method D).

المصدر