تفاعل #1509589
ord-00384f123a3c4034ad603224e8256ae0
معادلة التفاعل
5-nitroisophtalic acid monoethyl ester
oxalyl chloride
DMF
→
title compound
3-Chlorocarbonyl-5-nitro-benzoic acid ethyl ester
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1تركيزconcentrated in vacuum
- 2أخرىThe residue was triturated with toluene
- 3تركيزagain concentrated in vacuum
الإجراء التجريبي
To a solution of 5-nitroisophtalic acid monoethyl ester (80 g) in DCM (700 ml) at 25° C. was added 2M oxalyl chloride solution in DCM (63 ml), and DMF (5 ml). The reaction was stirred for 2 h and then concentrated in vacuum. The residue was triturated with toluene and again concentrated in vacuum leaving the title compound (60 g). Rt=1.40 min for derivatised methylester (method D).