تفاعل #1509588

معادلة التفاعل

Methyl 3-(tert.-butoxycarbonylamino)-5-tert-butylbenzoate

TFA

→

ethyl 3-amino-5-tert-butylbenzoate

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated in vacuum
2. 2
   workup.DISSOLUTIONThe residue was dissolved in DCM
3. 3
   استخلاصextracted with aqueous sodium bicarbonate solution
4. 4
   أخرىThe organic layer was separated
5. 5
   تجفيفdried over sodium sulphate
6. 6
   تركيزconcentrated in vacuum

الإجراء التجريبي

Methyl 3-(tert.-butoxycarbonylamino)-5-tert-butylbenzoate (0.42 g) was dissolved in DCM (5 ml). To the resulting solution, TFA (1 ml) was added, the mixture was stirred for 30 min at room temperature and then concentrated in vacuum. The residue was dissolved in DCM and extracted with aqueous sodium bicarbonate solution. The organic layer was separated, dried over sodium sulphate and concentrated in vacuum to yield ethyl 3-amino-5-tert-butylbenzoate (0.28 g), which was used for the synthesis of example 112 without further purification.

المصدر