تفاعل #1502

معادلة التفاعل

Chloromethyl chloroformate

cholesterol

Pyridine

→

3-(Chloromethoxycarbonyl) Cholesterol

المذيبات

CH2Cl2

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe solution was cooled
2. 2
   درجة الحرارةHeat
3. 3
   أخرىwas produced
4. 4
   أخرىthe reaction gave a clear solution from
5. 5
   غسيلwashed with 0.5M HCl (50 ml) and water (3×25 ml)
6. 6
   أخرىAfter treatment with MgSO4, the solution was evaporated to dryness

الإجراء التجريبي

Chloromethyl chloroformate (1.96 g, 15.2 mmol) and cholesterol (5.0 g, 12.9 mmol) was dissolved in CH2Cl2 (10 ml). The solution was cooled. Pyridine (1.21 g, 15.3 mmol) was dripped into the stirred solution over 5 minutes. Heat was produced and the reaction gave a clear solution from a somewhat unclear starting solution. After 24 hours at room temperature, the mixture was diluted with CH2Cl2 (50 ml), washed with 0.5M HCl (50 ml) and water (3×25 ml). After treatment with MgSO4, the solution was evaporated to dryness.

المصدر