تفاعل #1496725

معادلة التفاعل

1-aminocyclohexanecarboxylic acid

trimethylsilyl diazomethane

→

methyl 1-amino-cyclohexanecarboxylate

المردود 52.0%

المذيبات

tetrahydrofuran-methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooling
2. 2
   workup.STIRRINGthe mixture was stirred overnight
3. 3
   تركيزThe reaction mixture was concentrated in vacuo
4. 4
   workup.ADDITIONto the residue were added successively diethylether-hexane (1/1)
5. 5
   ترشيحThe precipitates were collected by filtration
6. 6
   أخرىdried

الإجراء التجريبي

To a solution of 1-aminocyclohexanecarboxylic acid (600 mg) in tetrahydrofuran-methanol was added dropwise trimethylsilyl diazomethane (4.2 mL) under ice-cooling and stirring, and the mixture was stirred overnight. The reaction mixture was concentrated in vacuo, and to the residue were added successively diethylether-hexane (1/1) and a solution of 4N hydrochloric acid in ethyl acetate (1.05 mL). The precipitates were collected by filtration and dried to give methyl 1-amino-cyclohexanecarboxylate (423 mg, yield: 52%) as a white powder.

المصدر