تفاعل #1493
ord-e3e7b7ca98e641d6a2d408b95787c8d2
معادلة التفاعل
المتفاعلات
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1أخرىwas quenched by the addition of 10% aqueous HCl
- 2استخلاصThe mixture was extracted with EtOAc
- 3غسيلthe combined organic layers washed with H2O and saturated aqueous NaCl
- 4تجفيفbefore being dried over Na2SO4
- 5أخرىRemoval of the solvents under pressure
الإجراء التجريبي
To a solution of methyl 5,5-dimethyl-5,6-dihydro-8-(phenylthio)-naphthalene-2-carboxylate (Compound E18, 300.0 mg, 0.926 mmol) in 4.0 mL of EtOH and 2.0 mL THF was added NaOH (200.0 mg, 5.00 mmol; 5.0 mL of a 1N aqueous solution). After stirring overnight at room temperature the reaction was quenched by the addition of 10% aqueous HCl. The mixture was extracted with EtOAc and the combined organic layers washed with H2O and saturated aqueous NaCl before being dried over Na2SO4. Removal of the solvents under pressure afforded the title compound as a yellow solid.