تفاعل #1491

معادلة التفاعل

2-trimethylsilylethyl 4-[[(5,5-dimethyl-5,6-dihydro-8-(2-thienyl)-naphthalen-2-yl)carbonyl]oxy]-benzoate

tetrabutylammonium fluoride

→

4-[[(5,5-Dimethyl-5,6-dihydro-8-(2-thienyl)-naphthalen-2-yl)carbonyl]oxy]-benzoic acid

المذيبات

THF

THF

EtOAc

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with H2O and saturated aqueous NaCl
2. 2
   تجفيفbefore being dried over MgSO4
3. 3
   أخرىThe solvents were removed under reduced pressure
4. 4
   غسيلthe residue washed with hot acetonitrile leaving the product as a colorless solid

الإجراء التجريبي

To a solution of 2-trimethylsilylethyl 4-[[(5,5-dimethyl-5,6-dihydro-8-(2-thienyl)-naphthalen-2-yl)carbonyl]oxy]-benzoate (Compound E10, 100.0 mg, 0.198 mmol) in 2.0 mL THF at room temperature was added 155.3 mg of tetrabutylammonium fluoride (0.594 mmol 0.6 mL of a 1M solution in THF). After stirring overnight the reaction was diluted with EtOAc and washed with H2O and saturated aqueous NaCl before being dried over MgSO4. The solvents were removed under reduced pressure and the residue washed with hot acetonitrile leaving the product as a colorless solid.

المصدر