تفاعل #1487970

معادلة التفاعل

NaBH4

3,5-dibromosalicylaldehyde

NaBH4

→

2-hydroxy-3,5-dibromobenzenemethanol

المردود 94.0%

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe mixture was stirred for another 2 hours
2. 2
   أخرىThe solvent was removed under vacuum
3. 3
   أخرىthe resulting white solid was re-precipitated in water
4. 4
   ترشيحThe product was collected as a white solid by vacuum filtration (10.1 grams, 94% yield)

الإجراء التجريبي

To a stirred solution of 3,5-dibromosalicylaldehyde (10.6 grams, 38 mmol) in MeOH (70 mL), was added NaBH4 (4.3 grams, 115 mmol) in small portions and the solution was stirred for 1.5 hours. Another batch of NaBH4 (2.0 grams, 52 mmol) was added in small portions and the mixture was stirred for another 2 hours. The solvent was removed under vacuum and the resulting white solid was re-precipitated in water. The product was collected as a white solid by vacuum filtration (10.1 grams, 94% yield).

المصدر