تفاعل #1483129

معادلة التفاعل

squaric acid

2-(methyl(3-acetaminophenyl)amino)ethan-1-ol

n-BuOH

→

desired compound

2,4-bis(2-acetamino-4-((2-hydroxyethyl)(methyl)amino)phenyl)cyclobuta-1,3-dien-1,3-diol

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was heated
2. 2
   أخرىto remove water
3. 3
   أخرىgenerated during the reaction
4. 4
   أخرىthe reactant kept being reacted
5. 5
   درجة الحرارةthe reactant was cooled down
6. 6
   أخرىproducing crystals
7. 7
   ترشيحThe crystals were filtered
8. 8
   أخرىonce more recrystallized

الإجراء التجريبي

342 mg of squaric acid and 2 g of 2-(methyl(3-acetaminophenyl)amino)ethan-1-ol were put in a 100 mL 3-neck rounded bottom flask, and 40 mL of n-BuOH and 20 mL of toluene were added thereto. The mixture was heated and refluxed at 120° C. for 10 hours. Next, a Dean-Stark trap set was used to remove water generated during the reaction, and the reactant kept being reacted. When the reaction was complete, the reactant was cooled down, producing crystals. The crystals were filtered, several times cleaned with hexane, and once more recrystallized, obtaining a desired compound.

المصدر