تفاعل #1483126

معادلة التفاعل

squaric acid

2-(methyl(3-butoxyphenyl)amino)ethan-1-ol

n-BuOH

→

desired compound

2,4-bis(2-n-butoxy-4-((2-hydroxyethyl)(methyl)amino)phenyl)cyclobuta-1,3-dien-1,3-diol

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was heated
2. 2
   أخرىto remove water
3. 3
   أخرىgenerated from the reactant during the reaction
4. 4
   أخرىkept being reacted
5. 5
   درجة الحرارةthe reactant was cooled down
6. 6
   أخرىproducing crystals
7. 7
   ترشيحThe crystals was filtered
8. 8
   غسيلseveral times washed with hexanes
9. 9
   أخرىonce more recrystallized

الإجراء التجريبي

342 mg of squaric acid and 2.14 g of 2-(methyl(3-butoxyphenyl)amino)ethan-1-ol was put in a 100 mL 3-necked round bottom flask, and 40 mL of n-BuOH and 20 mL of toluene were added thereto. The mixture was heated and refluxed at 120° C. for 7 hour. Then, a Dean-Stark trap set was used to remove water generated from the reactant during the reaction and kept being reacted. When the reaction was complete, the reactant was cooled down, producing crystals. The crystals was filtered, several times washed with hexanes, and once more recrystallized, obtaining a desired compound.

المصدر