تفاعل #1483108

معادلة التفاعل

2-bromo-2-methylpropionyl bromide

tridecan-2-ol

2-tridecanol

triethylamine

→

98

المردود 97.6%

tridecen-2-yl 2-bromopropanoate

المردود 97.6%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was quenched with saturated sodium bicarbonate solution
2. 2
   workup.STIRRINGstirred for 15 minutes at 25-35° C
3. 3
   أخرىThe aqueous and organic layers were separated
4. 4
   غسيلThe organic layer was washed with brine
5. 5
   غسيلthe combined organic layers were washed with brine solution
6. 6
   تجفيفThe organic layer was dried over Na2SO4
7. 7
   تركيزconcentrated under vacuum

الإجراء التجريبي

To a stirred solution of tridecan-2-ol 68 (5 g, 24.9 mmol) in toluene (50 mL) was added triethylamine (3.5 mL, 27.45 mmol)) and followed by 2-bromo-2-methylpropionyl bromide 97 (6.31 g, 27.45 mmol) at 5-10° C. The reaction mixture was stirred for 3 hour at 55-60° C., and the reaction was monitored by TLC. The reaction mixture was quenched with saturated sodium bicarbonate solution and stirred for 15 minutes at 25-35° C. The aqueous and organic layers were separated. The organic layer was washed with brine, and the combined organic layers were washed with brine solution. The organic layer was dried over Na2SO4 and concentrated under vacuum to afford crude 98 (8.1 g, yield: 96%) as a liquid.

المصدر