تفاعل #1482247

ord-c25a99d1f0d24f7a88b414dc9bb2b8f7

معادلة التفاعل

CCC1OC(=O)CC(OC(C)=O)C(C)C(OC2OC(C)C(OC3CC(C)(O)C(O)C(C)O3)C(N(C)C)C2O)C(CC=O)CC(C)C(=O)/C=C/C(C)=C/C1COC1OC(C)C(O)C(OC)C1OC
3-acetyltylosin
CCCC(N)C(=O)O
DL-norvaline
CC(C)C[C@H](N)C(=O)O
L-leucine
→
CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC
tylosin
CC(C)C[C@H](N)C(=O)O
L-leucine

المتفاعلات

—
isovaleryl
CCC1OC(=O)CC(OC(C)=O)C(C)C(OC2OC(C)C(OC3CC(C)(O)C(O)C(C)O3)C(N(C)C)C2O)C(CC=O)CC(C)C(=O)/C=C/C(C)=C/C1COC1OC(C)C(O)C(OC)C1OC
3-acetyltylosin
CCCC(N)C(=O)O
DL-norvaline
CC(C)C[C@H](N)C(=O)O
L-leucine

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىA similar cultivation and reaction as in Example 1

الإجراء التجريبي

A similar cultivation and reaction as in Example 1 was carried out by substituting L-leucine as the isovaleryl donor for DL-norvaline. From 60 g of tylosin and 15 g of L-leucine, about 900 mg of white crystals of 4"-isovaleryltylosin and 17 g of white crystals of 3-acetyltylosin were obtained.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US04201843uspto-grants-1980_05