تفاعل #1473966

معادلة التفاعل

1-ethoxycarbonyl-4-((benzothiazol-2-yl)methyl)piperidine

1-Ethoxycarbonyl-4-((Benzothiazol-2-yl)methyl)piperidine

→

title compound

المردود 78.6%

4-((Benzothiazol-2-yl)methyl)piperidine

المردود 78.6%

المذيبات

EtOH

KOH

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was partitioned between H2O and EtOAc
2. 2
   استخلاصAqueous phase was extracted with EtOAc (3×)
3. 3
   غسيلThe combined organic phases were washed with sat'd NaCl
4. 4
   تجفيفdried over anhydrous MgSO4
5. 5
   تركيزConcentration

الإجراء التجريبي

A solution of 300 mg of 1-ethoxycarbonyl-4-((benzothiazol-2-yl)methyl)piperidine (from EXAMPLE 163, Step E) in 5 mL of EtOH and 5 mL of KOH (50 wt. % solution) was refluxed for 18 h. The reaction mixture was partitioned between H2O and EtOAc. Aqueous phase was extracted with EtOAc (3×). The combined organic phases were washed with sat'd NaCl and dried over anhydrous MgSO4. Concentration afforded 180 mg of the title compound as a brown solid.

المصدر