تفاعل #1470439

معادلة التفاعل

Succinic anhydride

2,6-diisopropylphenol

→

2,6-diisopropylphenyl hydrogen succinate

المردود 80.2%

المذيبات

triethylamine

ظروف التفاعل

المعالجة

1. 1
   أخرىsolvents were removed under vacuum
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water
3. 3
   workup.ADDITIONadded to an iced solution of dilute hydrochloric acid
4. 4
   ترشيحThe precipitated product was filtered
5. 5
   أخرىrecrystallized from ethanol-water

الإجراء التجريبي

Succinic anhydride (14 g, 140 mmol) and dimethylaminopyridine (0.02 g, 0.16 mmol) were added to a solution of 2,6-diisopropylphenol (20.8 ml, 112 mmol) in triethylamine (50 ml) under nitrogen. After 16 hr at room temperature, solvents were removed under vacuum. The residue was dissolved in water and added to an iced solution of dilute hydrochloric acid. The precipitated product was filtered and recrystallized from ethanol-water to yield 25.0 g (80.2% yield) of 2,6-diisopropylphenyl hydrogen succinate (propofol hemisuccinate), mp 101-102° C.

المصدر