تفاعل #1470438

معادلة التفاعل

thionyl chloride

α-aminolauric acid

isopropanol

→

α-Aminolauric acid isopropyl ester

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto reflux for two hours
2. 2
   درجة الحرارةAfter cooling off to room temperature
3. 3
   تركيزthe batch is completely concentrated by evaporation
4. 4
   workup.STIRRINGshaken out from aqueous sodium carbonate solution
5. 5
   أخرىThe organic phase is dried on magnesium sulfate
6. 6
   ترشيحfiltered
7. 7
   تركيزconcentrated by evaporation

الإجراء التجريبي

50 ml of isopropanol is stirred at 0° C. under argon and mixed drop by drop with 3.12 ml (41.6 mmol) of thionyl chloride. 30 minutes later, 7.40 g (34.4 mmol) of α-aminolauric acid is added in portions, stirred for one hour at room temperature and the batch then is allowed to reflux for two hours. After cooling off to room temperature, the batch is completely concentrated by evaporation, the residue is taken up in tert-butyl methyl ether and shaken out from aqueous sodium carbonate solution. The organic phase is dried on magnesium sulfate, filtered and concentrated by evaporation.

المصدر