تفاعل #1461708

معادلة التفاعل

sodium hydride

tetraethylene glycol

mesylate

tetraethylene glycol monobenzylether

→

compound 25

المردود 34.5%

Octaethylene glycol monobenzylether

المردود 34.5%

المذيبات

tetrahydrofuran

tetrahydrofuran

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added dropwise
2. 2
   workup.STIRRINGthe reaction mixture was stirred overnight
3. 3
   أخرىThe crude reaction mixture
4. 4
   ترشيحwas filtered through Celite (washed, CH2Cl2, 250 mL)
5. 5
   غسيلthe filtrate was washed H2O, dried MgSO4
6. 6
   أخرىevaporated to dryness
7. 7
   أخرىThe resultant oil was chromatographed (silica, ethyl acetate/methanol, 10:1)
8. 8
   أخرىchromatographed (silica, chloroform/methanol, 25:1)

الإجراء التجريبي

To a solution of tetrahydrofuran (140 mL) containing sodium hydride (0.43 g, 18 mmol) was added dropwise a solution of monodispersed tetraethylene glycol (3.5 g, 18 mmol) in tetrahydrofuran (10 mL) and the reaction mixture was stirred for 1 h. Then mesylate of monodispersed tetraethylene glycol monobenzylether 24 (6.0 g, 16.5 mmol) dissolved in tetrahydrofuran (10 mL) was added dropwise and the reaction mixture was stirred overnight. The crude reaction mixture was filtered through Celite (washed, CH2Cl2, 250 mL) and the filtrate was washed H2O, dried MgSO4, and evaporated to dryness. The resultant oil was chromatographed (silica, ethyl acetate/methanol, 10:1) and chromatographed (silica, chloroform/methanol, 25:1) to afford the monodispersed compound 25 as a clear oil (2.62 g, 34% yield).

المصدر