تفاعل #1447203

معادلة التفاعل

2-(benzyloxy)-6-bromopyridine

pyrrolidine

water

→

2-(benzyloxy)-6-(pyrrolidin-1-yl)pyridine

المردود 95.3%

المذيبات

ethyl acetate hexane

ظروف التفاعل

المعالجة

1. 1
   أخرىthe mixture was reacted
2. 2
   أخرىat 150° C.
3. 3
   أخرىfor 10 min
4. 4
   استخلاصextracted twice with 100 ml portions of ethyl acetate
5. 5
   أخرىthe organic layer was separated
6. 6
   أخرىdried over anhydrous and
7. 7
   أخرىto remove the solvent
8. 8
   أخرىThe residue thus obtained

الإجراء التجريبي

In a dried microwave reactor, 526 mg (2.0 mmol) of 2-(benzyloxy)-6-bromopyridine and 1.70 ml (20 mmol) of pyrrolidine were placed, and the mixture was reacted using microwave at 150° C. for 10 min. The reaction mixture was mixed with 20 ml of water, extracted twice with 100 ml portions of ethyl acetate, and the organic layer was separated dried over anhydrous and kept under a reduced pressure to remove the solvent. The residue thus obtained was subjected to column chromatography using 10% ethyl acetate/hexane as an eluent to obtain 485 mg (yield 95%) of 2-(benzyloxy)-6-(pyrrolidin-1-yl)pyridine.

المصدر