تفاعل #1447112

معادلة التفاعل

Et3N

1-naphthyl dichlorophosphate

(25)-1-butoxy-1-oxopropan-2-aminium chloride

→

n-Butyl N-[chloro(1-naphthyloxy)phosphoryl]-L-alaninate

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   workup.WAITthe reaction was left
2. 2
   درجة الحرارةto warm to RT overnight
3. 3
   أخرىAll volatiles were removed
4. 4
   غسيلthe resulting white solid was washed with Et2O
5. 5
   ترشيحfiltered
6. 6
   أخرىevaporated in vacuo
7. 7
   أخرىto obtain a colorless oil
8. 8
   workup.ADDITIONas a 1:1 mixture of diastereoisomers

الإجراء التجريبي

To 1-naphthyl dichlorophosphate in DCM (0.086 M) was added (25)-1-butoxy-1-oxopropan-2-aminium chloride (1.0 eq.). After cooling to −78° C., neat Et3N (2.0 eq.) was added and the reaction was left to warm to RT overnight. All volatiles were removed and the resulting white solid was washed with Et2O, filtered and evaporated in vacuo to obtain a colorless oil as a 1:1 mixture of diastereoisomers. 31P NMR (400 MHz, CDCl3): δ 8.39 and 8.11 ppm.

المصدر