تفاعل #1447102

معادلة التفاعل

KOtBu

1-Bromo-4-cyano-3-fluoro-5-(4-ethyl-phenyl)-benzene

KOtBu

HCl

cyclobutanol

→

title compound

1-Bromo-4-cyano-3-cyclobutoxy-5-(4-ethyl-phenyl)-benzene

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONcharged with a stir bar
2. 2
   workup.ADDITIONis added
3. 3
   استخلاصThe resulting mixture is extracted with ethyl acetate
4. 4
   تجفيفthe combined organic phases are dried (sodium sulphate)
5. 5
   أخرىthe solvent is removed

الإجراء التجريبي

1-Bromo-4-cyano-3-fluoro-5-(4-ethyl-phenyl)-benzene (1.2 g) is added to a flask charged with a stir bar, KOtBu (0.5 g) and cyclobutanol (3.0 g). The solution is stirred at room temperature overnight, before another portion of KOtBu (0.2 g) is added. The solution is stirred for another 5 h and then neutralized with 1 M aqueous HCl solution. The resulting mixture is extracted with ethyl acetate, the combined organic phases are dried (sodium sulphate) and the solvent is removed to give the title compound.

المصدر