تفاعل #1447098

معادلة التفاعل

hydrochloric acid

N-[4-bromo-2-(4-ethyl-benzyl)-5-methoxy-phenyl]-acetamide

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title compound

4-Bromo-2-(4-ethyl-benzyl)-5-methoxy-phenylamine

المذيبات

isopropanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe solution is heated
2. 2
   درجة الحرارةat reflux temperature for 8 h
3. 3
   تركيزconcentrated under reduced pressure
4. 4
   أخرىto remove most of the alcohol
5. 5
   workup.ADDITIONAqueous NaHCO3 solution is added to the rest
6. 6
   استخلاصthe resulting mixture is extracted twice with ethyl acetate
7. 7
   غسيلThe combined organic extracts are washed with brine
8. 8
   تجفيفdried (Na2SO4)
9. 9
   تركيزconcentrated

الإجراء التجريبي

Half-concentrated hydrochloric acid (5 mL) is added to a solution of N-[4-bromo-2-(4-ethyl-benzyl)-5-methoxy-phenyl]-acetamide (2.8 g) in isopropanol (20 mL). The solution is heated at reflux temperature for 8 h and then concentrated under reduced pressure to remove most of the alcohol. Aqueous NaHCO3 solution is added to the rest and the resulting mixture is extracted twice with ethyl acetate. The combined organic extracts are washed with brine, dried (Na2SO4) and concentrated to give the title compound.

المصدر