تفاعل #1447093

معادلة التفاعل

water

Sodium methoxide

(2-bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone

sodium methoxide

→

(2-Bromo-4-methoxy-phenyl)-(4-ethyl-phenyl)-methanone

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONis added
2. 2
   استخلاصthe resulting mixture is extracted with ethyl acetate
3. 3
   تجفيفThe organic phase is dried (sodium sulphate)
4. 4
   أخرىthe solvent is removed
5. 5
   أخرىthe residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1)

الإجراء التجريبي

Sodium methoxide (10.5 g) is added portionwise to (2-bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone (43.0 g) dissolved in DMF (200 mL). The solution is stirred overnight, before another portion of sodium methoxide (5.5 g) is added. After another 3 h of stirring, water is added and the resulting mixture is extracted with ethyl acetate. The organic phase is dried (sodium sulphate), the solvent is removed and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1).

المصدر