تفاعل #1447086

معادلة التفاعل

D-Homophenylalanine hydrochloride

benzyl alcohol

p-toluenesulfonic acid monohydrate

→

title product

المردود 83.7%

D-Homophenylalanine Benzyl ester Tosylate

المردود 83.7%

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux in Dean Stark apparatus during 5 hrs
2. 2
   workup.DISTILLATIONafter which time additional benzene (100 mL) was distilled from reaction mixture
3. 3
   أخرىThe residue was triturated with diethyl ether
4. 4
   ترشيحthe solid was filtered
5. 5
   أخرىdried

الإجراء التجريبي

A solution of D-Homophenylalanine hydrochloride (1.7 g, 7.93 mmol), benzyl alcohol (7.2 mL, 64.0 mmol) and p-toluenesulfonic acid monohydrate (1.8 g, 9.5 mmol) in benzene (30 mL) was heated at reflux in Dean Stark apparatus during 5 hrs, after which time additional benzene (100 mL) was distilled from reaction mixture. The residue was triturated with diethyl ether, the solid was filtered and dried to give title product (2.93 g).

المصدر