تفاعل #1435753

معادلة التفاعل

3-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-propylamine dihydrochloride

N,N-diisopropylethylamine

3-Chloro-4,6-difluorobenzenesulfonyl chloride

→

solid

المردود 87.0%

5-Chloro-N-[3-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-propyl]-2,4-difluoro-benzenesulfonamide

المردود 87.0%

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   غسيلThe resulting solution was washed with water (3×20 mL)
2. 2
   تجفيفdried over Na2SO4
3. 3
   أخرىevaporated to dryness
4. 4
   workup.DISSOLUTIONThe free base was dissolved in 2-propanol (5 mL)
5. 5
   أخرىThe product was crystallized in 2-propanol (5 mL)
6. 6
   ترشيحcollected by filtration, and vacuum
7. 7
   أخرىdried

الإجراء التجريبي

A solution of 3-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-propylamine dihydrochloride (323 mg, 1 mmol), N,N-diisopropylethylamine (517 mg, 4 mmol) in CH2Cl2(15 mL), was added 3-Chloro-4,6-difluorobenzenesulfonyl chloride (259 mg, 1.05 mmol) and was stirred overnight at room temperature. The resulting solution was washed with water (3×20 mL) and dried over Na2SO4, and evaporated to dryness. The free base was dissolved in 2-propanol (5 mL). The product was crystallized in 2-propanol (5 mL) collected by filtration, and vacuum dried to give a white solid (401 mg, 87%).

المصدر