تفاعل #1435746

معادلة التفاعل

Dimethyl-[1-(4-nitro-phenyl)-piperidin-4-yl]-amine

thiocarbonyl diimidazole

water

→

[1-(4-Isothiocyanato-phenyl)-piperidin-4-yl]-dimethyl-amine

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with diethyl ether
2. 2
   تجفيفThe extract was dried with sodium sulfate
3. 3
   تركيزconcentrated
4. 4
   أخرىto give a pale yellow solid

الإجراء التجريبي

Dimethyl-[1-(4-nitro-phenyl)-piperidin-4-yl]-amine (Example 2, 1.1 g, 5.0 mmol) was dissolved in DMF (5 mL). To the stirred solution, thiocarbonyl diimidazole (Aldrich, 1.18 g, 90%, 6 mmol) was added and the solution was stirred at room temperature for 80 minutes. The mixture was poured into water and extracted with diethyl ether. The extract was dried with sodium sulfate and concentrated to give a pale yellow solid. 1.12 g, 85%. MS (m+H)+: 262.

المصدر