تفاعل #1435734

معادلة التفاعل

5,7-dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine

di-n-propylamine

chloroform

→

5-(di-n-propylamino)-6-(2,4,6-trifluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine

المردود 83.1%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto cool
2. 2
   تجفيفThe separated organic layer was dried over sodium sulfate
3. 3
   تركيزconcentrated

الإجراء التجريبي

A mixture of 0.095 g of 5,7-dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine and 0.12 g of di-n-propylamine was heated at 80° C. for one hour. The reaction mixture was allowed to cool, and chloroform and water were added thereto. The separated organic layer was dried over sodium sulfate and concentrated. The residue was subjected to silica gel column chromatography to give 0.095 g of 5-(di-n-propylamino)-6-(2,4,6-trifluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine.

المصدر