تفاعل #1435731

معادلة التفاعل

hydrochloric acid

water

water

ethyl (2-chloro-6-fluorophenyl)acetoacetate

aminoimidazole hydrochloride

1,5-diazabicyclo[4.3.0]-5-nonene

→

5-hydroxy-6-(2-chloro-6-fluorophenyl)-7-methylimidazo[1,2-a]pyrimidine

المذيبات

chloroform

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto cool
2. 2
   ترشيحthe precipitate was filtered

الإجراء التجريبي

A mixture of 1.29 g of ethyl (2-chloro-6-fluorophenyl)acetoacetate, 0.60 g of aminoimidazole hydrochloride, 1.24 g of 1,5-diazabicyclo[4.3.0]-5-nonene (DBN) and 5 ml of N,N-dimethylformamide was heated at 100° C. for 14 hours. The reaction mixture was allowed to cool, and chloroform and water were added thereto. To the separated water layer, conc. hydrochloric acid was added and the precipitate was filtered, which was followed to subject to silica gel chromatography to give 0.16 g of 5-hydroxy-6-(2-chloro-6-fluorophenyl)-7-methylimidazo[1,2-a]pyrimidine.

المصدر