تفاعل #1435729

معادلة التفاعل

chloroform

5,7-dichloro-6-(2-chloro-6-fluorophenyl)imidazo[1,2-a]pyrimidine

4-methylpiperidine

→

5-(4-methylpiperidin-1-yl)-6-(2-chloro-6-fluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine

المردود 96.7%

المذيبات

water

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةUnder ice-cooling
2. 2
   تجفيفdried over sodium sulfate
3. 3
   تركيزconcentrated

الإجراء التجريبي

Under ice-cooling, 0.63 g of 5,7-dichloro-6-(2-chloro-6-fluorophenyl)imidazo[1,2-a]pyrimidine and 0.79 g of 4-methylpiperidine were mixed. The reaction mixture was allowed to stand at room temperature for 10 minutes, and chloroform and water were added thereto. The separated organic layer was with water, dried over sodium sulfate and concentrated. The residue was subjected to silica gel chromatography to give 0.73 g of 5-(4-methylpiperidin-1-yl)-6-(2-chloro-6-fluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine.

المصدر