تفاعل #1435726

معادلة التفاعل

ammonium chloride

5,7-dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine

4-methylpiperidine

→

5-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine

المردود 80.9%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةUnder ice-cooling
2. 2
   غسيلThe separated organic layer was washed with water
3. 3
   تجفيفdried over sodium sulfate
4. 4
   تركيزconcentrated
5. 5
   غسيلThe residue was washed with t-butyl methyl ether

الإجراء التجريبي

Under ice-cooling, 0.64 g of 5,7-dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine and 0.79 g of 4-methylpiperidine were mixed. The mixture was allowed to stand at room temperature for one hour, and chloroform and aqueous saturated ammonium chloride solution were added to the reaction mixture. The separated organic layer was washed with water, dried over sodium sulfate and concentrated. The residue was washed with t-butyl methyl ether to give 0.62 g of 5-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine

المصدر