تفاعل #1435725

معادلة التفاعل

diethyl (2,4,6-trifluorophenyl)malonate

2-aminoimidazole hydrochloride

DBU

N,N-dimethylformamide

→

5,7-dihydroxy-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine

المردود 78.3%

المذيبات

water

chloroform

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto cool to room temperature
2. 2
   تركيزThe separated water layer was concentrated
3. 3
   workup.ADDITIONthe residue was diluted with water and conc. hydrochloric acid
4. 4
   workup.ADDITIONwas added
5. 5
   درجة الحرارةunder ice-cooling
6. 6
   أخرىThe precipitation
7. 7
   ترشيحwas filtered
8. 8
   أخرىdried

الإجراء التجريبي

A mixture of 2.90 g of diethyl (2,4,6-trifluorophenyl)malonate, 2.39 g of 2-aminoimidazole hydrochloride, 4.57 g of DBU and 10 ml of N,N-dimethylformamide was heated at 100° C. for 6 hours. After allowing the reaction mixture to cool to room temperature, chloroform and water were added thereto. The separated water layer was concentrated, the residue was diluted with water and conc. hydrochloric acid was added thereto under ice-cooling. The precipitation was filtered and dried to give 2.2 g of 5,7-dihydroxy-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine.

المصدر