تفاعل #1435687

معادلة التفاعل

benzyl cyanoformate

diethylenetriamine

triethylamine

→

Bis[2-(benzyloxycarbonylamino)-ethyl]-amine

المذيبات

dichloromethane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentration
2. 2
   أخرىby evaporation
3. 3
   غسيلthe organic phase is washed with sodium carbonate solution
4. 4
   تجفيفdried with sodium sulfate
5. 5
   workup.ADDITIONThe filtrate is mixed with hexane
6. 6
   ترشيحthe precipitate is filtered out
7. 7
   أخرىdried

الإجراء التجريبي

51.5 g (500 mmol) of diethylenetriamine and 139 ml (1 mol) of triethylamine are dissolved in dichloromethane and mixed at −20° C. with 161 g of benzyl cyanoformate (Fluka) in dichloromethane and then stirred overnight at room temperature. After the reaction is completed, concentration by evaporation is performed during draw-off, the residue is taken up in diethyl ether, the organic phase is washed with sodium carbonate solution and dried with sodium sulfate. The filtrate is mixed with hexane, the precipitate is filtered out and dried.

المصدر